Pharmacodynamics
Protein Drug Targets Proteins or other biomolecules like DNA,RNA, heparin and peptides to which the drug binds and which are responsible for the therapeutic efficacy of the drug. Types of protein targets :- enzymes receptors ion binding channels Transporters Receptors :- They are located on both the cell surface and within the cell where medicine produce their beneficial effects in various diseases states. Receptors are typically envisaged as cell surface recognition sites for endogenous hormones, neurotransmitters and neuromodulators. There are 4 types: - Ligand gated receptor Enzyme linked receptor G-protein coupled receptor Intracellular receptor Drug interacts with receptor by means of chemical forces or bonds:- Covalent Electrostatic Lipophillic Hydrogen Agonist : - An agent which activates a receptor to produce an effect similar to that of the physiological signal molecule Antagonist :- An agent which prevents the action of an agonist on a receptor or the subsequent response