EVOLUTION OF DRUGS

 Definition 

Berries of coffee plant

   A drug is defined as any chemical agent that affects the living protoplasm.

Drug invention vs Drug discovery

A drug discovery is not intentional.

A drug invention  is defined as the intentional process

Poisonous mushroom

by which the drug is sculpted by experimentation &
 
optimization of individual properties .

 Early experiences in chemistry

Goats went insane after eating the berries of coffee plant 

Professional poisoners used mushrooms and Belladona 

Atropa belladona
source: www.fs.fd.usa

Curare was used by South American tribes for hunting

Poppy  was used to relieve pain

Chinese herb Ma Huang was used as a circulatory stimulant

Rise of Organic chemistry

PAUL EHLRICH worked on dyes 

He invented arsphenamine named as 

Salvarsan - Salvation of humankind 

PAUL EHLRICH
Father of chemotherapy

curare

 

poppy

                                                                        

 Organic arsenicals was used for the treatment of syphilis

 GERHARD DOMAGYK used prontosil treating
  streptococcus infections  

   

GERHARD DOMAGYK
German pathologist

Further led to the era of antibiotic chemotherapy